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HIT103634779
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HIT103634779
  • HIT ID:HIT103634779
  • Cas No:480-11-5
  • Common Name:Oroxylin A
  • alias:Baicalein 6-methyl ether, 6-Methoxybaicalein
    alias:Baicalein 6-methyl ether, 6-Methoxybaicalein
  • IUPAC:5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one
    IUPAC:5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one
  • InChIKey:LKOJGSWUMISDOF-UHFFFAOYSA-N
  • Molecular Formula:C16H12O5
  • Molecular Weight:284.267
  • Hydrogen Bond Donor (HBD):2
  • Hydrogen Bond Acceptor (HBA):5
  • LogP:2.853
  • SMILES:COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccccc1
    SMILES:COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccccc1
  • 1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.
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