Name: Z640
Rating: 5 (10 reviews)

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HIT ID:HIT103671874
Cas No:353793-07-4
常用名:Z640
IUPAC:2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)-N-[4-(morpholin-4-yl)phenyl]acetamide
IUPAC:2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)-N-[4-(morpholin-4-yl)phenyl]acetamide
InChI key:NUPBIIGSDCCPHO-UHFFFAOYSA-N

分子式:C22H26N4O3
分子量:394.475
氢键供体数 (HBD):3
氢键受体数 (HBA):7
LogP:1.93
SMILES:Cc1cc2NC(CC(=O)Nc3ccc(cc3)N3CCOCC3)C(=O)Nc2cc1C
SMILES:Cc1cc2NC(CC(=O)Nc3ccc(cc3)N3CCOCC3)C(=O)Nc2cc1C

Z640 an aPKC agonist. Z640 was further confirmed as a non‑selective aPKC agonist that can activate the kinase activity of both PKCι and PKCζ. In the cell‑based assay, Z640 was found to protect neuronal cell lines from amyloid‑β (Aβ) oligomer‑induced cell death by reducing reactive oxygen species production and restore mitochondrial function. In addition, Z640 could reduce Aβ40 generation in a dose‑dependent manner and shift amyloid precursor protein processing towards the non‑amyloid pathway

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