Name: Terrein
Rating: 5 (10 reviews)

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HIT ID:HIT103796556
Cas No:582-46-7
常用名:Terrein
别名:土曲霉酮, Terrain, NSC-291308, NSC291308, NSC 291308, (+)Terrein
别名:土曲霉酮, Terrain, NSC-291308, NSC291308, NSC 291308, (+)Terrein
IUPAC:(4S,5R)-4,5-dihydroxy-3-[(1E)-prop-1-en-1-yl]cyclopent-2-en-1-one
IUPAC:(4S,5R)-4,5-dihydroxy-3-[(1E)-prop-1-en-1-yl]cyclopent-2-en-1-one
InChI key:MHOOPNKRBMHHEC-HZIBQTDNSA-N

分子式:C8H10O3
分子量:154.165
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:0.022
SMILES:C\C=C\C1=CC(=O)[C@H](O)[C@H]1O |t:3|
SMILES:C\C=C\C1=CC(=O)[C@H](O)[C@H]1O |t:3|

Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.

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