Name: Terrein
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HIT ID:HIT103796556
Cas No:582-46-7
Common Name:Terrein
alias:Terrain, NSC-291308, NSC291308, NSC 291308, (+)Terrein
alias:Terrain, NSC-291308, NSC291308, NSC 291308, (+)Terrein
IUPAC:(4S,5R)-4,5-dihydroxy-3-[(1E)-prop-1-en-1-yl]cyclopent-2-en-1-one
IUPAC:(4S,5R)-4,5-dihydroxy-3-[(1E)-prop-1-en-1-yl]cyclopent-2-en-1-one
InChIKey:MHOOPNKRBMHHEC-HZIBQTDNSA-N

Molecular Formula:C8H10O3
Molecular Weight:154.165
Hydrogen Bond Donor (HBD):2
Hydrogen Bond Acceptor (HBA):3
LogP:0.022
SMILES:C\C=C\C1=CC(=O)[C@H](O)[C@H]1O |t:3|
SMILES:C\C=C\C1=CC(=O)[C@H](O)[C@H]1O |t:3|

Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.

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