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HIT103841176
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HIT103841176
  • HIT ID:HIT103841176
  • Cas No:880399-00-8
  • Common Name:GPVI antagonist 2
  • IUPAC:4-(3-butoxyphenyl)-3-(2-hydroxyphenyl)-5-(3-hydroxypropyl)-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-6-one
    IUPAC:4-(3-butoxyphenyl)-3-(2-hydroxyphenyl)-5-(3-hydroxypropyl)-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-6-one
  • InChIKey:MLGZFHLZGVILRC-UHFFFAOYSA-N
  • Molecular Formula:C24H27N3O4
  • Molecular Weight:421.497
  • Hydrogen Bond Donor (HBD):3
  • Hydrogen Bond Acceptor (HBA):6
  • LogP:4.5482
  • SMILES:CCCCOc1cccc(c1)C1N(CCCO)C(=O)c2[nH]nc(c12)-c1ccccc1O
    SMILES:CCCCOc1cccc(c1)C1N(CCCO)C(=O)c2[nH]nc(c12)-c1ccccc1O
  • GPVI antagonist 2 (Compound 1) is a potential Glycoprotein VI (GPVI) antagonist, showing activity against collagen (IC50: 0.35 μM), CRP (IC50: 0.80 μM), convulxin (IC50: 195.2 μM), and thrombin (IC50: 81.38 μM), and is a promising anti-platelet agent.
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