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HIT104055489
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HIT104055489
  • HIT ID:HIT104055489
  • Cas No:330796-24-2
  • 常用名:Hedgehog Antagonist VIII
  • IUPAC:3-[4-chloro-3-(trifluoromethyl)phenyl]-1-{[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]methyl}urea
    IUPAC:3-[4-chloro-3-(trifluoromethyl)phenyl]-1-{[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]methyl}urea
  • InChI key:NYOXUHUPXGFHIB-UHFFFAOYSA-N
  • 分子式:C23H15ClF4N4O2
  • 分子量:490.84
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):3
  • LogP:5.082086
  • SMILES:Fc1ccc(cc1)-n1c(CNC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)nc2ccccc2c1=O
    SMILES:Fc1ccc(cc1)-n1c(CNC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)nc2ccccc2c1=O
  • Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.
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    TargetMolSC
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    OtavaSC
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    4-6周
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    ¥ 449.00
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  • 供应商
    AA BlocksBB
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    4-6周
    纯度
    -
    待询
    1

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