R-8507 | CAS 338773-13-0 | AnyMole

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HIT104435214

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HIT104435214

HIT ID:HIT104435214
Cas No:338773-13-0
常用名:R-8507
IUPAC:1-(4-chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
IUPAC:1-(4-chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
InChI key:PEOTYDSXVIEYAM-UHFFFAOYSA-N

分子式:C16H8ClF3N4
分子量:348.71
氢键供体数 (HBD):0
氢键受体数 (HBA):3
LogP:3.878667276
SMILES:FC(F)(F)c1nc2ccccc2n2c(nnc12)-c1ccc(Cl)cc1
SMILES:FC(F)(F)c1nc2ccccc2n2c(nnc12)-c1ccc(Cl)cc1

R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.

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