Name: ARN1468
Rating: 5 (10 reviews)

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HIT ID:HIT104732930
Cas No:1381459-14-8
常用名:ARN1468
IUPAC:4-(piperidine-4-carbonyl)-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-amine
IUPAC:4-(piperidine-4-carbonyl)-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-amine
InChI key:OOUGXIZAHWLQEM-UHFFFAOYSA-N

分子式:C16H17F3N4O2
分子量:354.333
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:2.45
SMILES:Nc1c(cnn1-c1ccc(OC(F)(F)F)cc1)C(=O)C1CCNCC1
SMILES:Nc1c(cnn1-c1ccc(OC(F)(F)F)cc1)C(=O)C1CCNCC1

ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].

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