Name: GPVI antagonist 3
Rating: 5 (10 reviews)

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HIT ID:HIT104875197
Cas No:-
常用名:GPVI antagonist 3
IUPAC:3-(2-hydroxy-5-methylphenyl)-5-(3-hydroxypropyl)-4-(4-methoxyphenyl)-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-6-one
IUPAC:3-(2-hydroxy-5-methylphenyl)-5-(3-hydroxypropyl)-4-(4-methoxyphenyl)-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-6-one
InChI key:PMWMTIDDNHPPEP-UHFFFAOYSA-N

分子式:C22H23N3O4
分子量:393.443
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:3.468
SMILES:COc1ccc(cc1)C1N(CCCO)C(=O)c2[nH]nc(c12)-c1cc(C)ccc1O
SMILES:COc1ccc(cc1)C1N(CCCO)C(=O)c2[nH]nc(c12)-c1cc(C)ccc1O

GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects, with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin. GPVI is a major collagen receptor on platelets, making it an ideal target for safe and effective antithrombotic treatment. Therefore, GPVI antagonist 3 holds potential as a novel antiplatelet agent [1].

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