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HIT105048659
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HIT105048659
  • HIT ID:HIT105048659
  • Cas No:54280-71-6
  • 常用名:Nemadipine-A
  • IUPAC:3,5-diethyl 2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
    IUPAC:3,5-diethyl 2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • InChI key:QABNLWXKUCMDBP-UHFFFAOYSA-N
  • 分子式:C19H18F5NO4
  • 分子量:419.348
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):4
  • LogP:4.483
  • SMILES:CCOC(=O)C1=C(C)NC(C)=C(C1c1c(F)c(F)c(F)c(F)c1F)C(=O)OCC |c:5,10|
    SMILES:CCOC(=O)C1=C(C)NC(C)=C(C1c1c(F)c(F)c(F)c(F)c1F)C(=O)OCC |c:5,10|
  • Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
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    ChembridgeSC
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    3-4周
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    ¥ 832.00
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