Name: Syntelin
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT105088172
Cas No:438481-33-5
常用名:Syntelin
IUPAC:2-({5-[({3-amino-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-5-yl}sulfanyl)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetic acid
IUPAC:2-({5-[({3-amino-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-5-yl}sulfanyl)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetic acid
InChI key:SPRISILOMIVCIR-UHFFFAOYSA-N

分子式:C21H20N6O2S3
分子量:484.61
氢键供体数 (HBD):2
氢键受体数 (HBA):7
LogP:4.11
SMILES:Nc1nc(SCc2nnc(SCC(O)=O)n2-c2ccccc2)nc2sc3CCCCc3c12
SMILES:Nc1nc(SCc2nnc(SCC(O)=O)n2-c2ccccc2)nc2sc3CCCCc3c12

Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor.

市场产品/服务共显示10个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~