Name: Nampt-IN-7
Rating: 5 (10 reviews)

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HIT ID:HIT105636988
Cas No:1223378-42-4
常用名:Nampt-IN-7
IUPAC:ethyl 4-[({[2-(2-methyl-1H-imidazol-1-yl)pyridin-4-yl]methyl}carbamoyl)amino]benzoate
IUPAC:ethyl 4-[({[2-(2-methyl-1H-imidazol-1-yl)pyridin-4-yl]methyl}carbamoyl)amino]benzoate
InChI key:REJWICBGFGQVML-UHFFFAOYSA-N

分子式:C20H21N5O3
分子量:379.42
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:2.748
SMILES:CCOC(=O)c1ccc(NC(=O)NCc2ccnc(c2)-n2ccnc2C)cc1
SMILES:CCOC(=O)c1ccc(NC(=O)NCc2ccnc(c2)-n2ccnc2C)cc1

Nampt-IN-7, also known as compound GF8, is a powerful NAMPT inhibitor exhibiting an IC50 value of 7.31 μM. It possesses significant cytotoxic effects against the human HepG2 hepatocellular carcinoma cell line, with an IC50 value of 24.28 μM [1].

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