Name: Poloxipan
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT106199499
Cas No:1239513-63-3;606955-72-0
常用名:Poloxipan
IUPAC:(2Z)-2-[(5-bromo-2-methoxyphenyl)methylidene]-6-methyl-2H,3H,7H-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
IUPAC:(2Z)-2-[(5-bromo-2-methoxyphenyl)methylidene]-6-methyl-2H,3H,7H-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
InChI key:UEMYVTYHECWXSR-WDZFZDKYSA-N

分子式:C14H10BrN3O3S
分子量:380.22
氢键供体数 (HBD):0
氢键受体数 (HBA):8
LogP:2.6615
SMILES:COc1ccc(Br)cc1\C=c1/sc2nc(=O)c(C)nn2c1=O
SMILES:COc1ccc(Br)cc1\C=c1/sc2nc(=O)c(C)nn2c1=O

Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc.

市场产品/服务共显示7个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~