Name: Pestalotin
Rating: 5 (10 reviews)

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HIT ID:HIT106514264
Cas No:34565-32-7
常用名:Pestalotin
IUPAC:(6S)-6-[(1S)-1-hydroxypentyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
IUPAC:(6S)-6-[(1S)-1-hydroxypentyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
InChI key:YFIMUDXPJZVJJO-UWVGGRQHSA-N

分子式:C11H18O4
分子量:214.261
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:1.236
SMILES:CCCC[C@H](O)[C@@H]1CC(OC)=CC(=O)O1 |c:10|
SMILES:CCCC[C@H](O)[C@@H]1CC(OC)=CC(=O)O1 |c:10|

Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities. It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 12.5, 50, 50, and 50 μg/ml, respectively). It is cytotoxic to HL-60, MKN45, LoVo, and A549 cells (IC50s = 64.87-182.92 μM). Pestalotin has been used as a standard for dereplication of natural products.

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