Name: CAY10721
Rating: 5 (10 reviews)

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HIT ID:HIT107386407
Cas No:848688-62-0
常用名:CAY10721
IUPAC:N-(3-hydroxyphenyl)-2-{8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-6-ylsulfanyl}acetamide
IUPAC:N-(3-hydroxyphenyl)-2-{8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-6-ylsulfanyl}acetamide
InChI key:ZXXJUSSVHKICFE-UHFFFAOYSA-N

分子式:C18H13N3O3S
分子量:351.38
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:2.915
SMILES:Oc1cccc(NC(=O)CSc2ncnc3c4ccccc4oc23)c1
SMILES:Oc1cccc(NC(=O)CSc2ncnc3c4ccccc4oc23)c1

CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.

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