Name: M04
Rating: 5 (10 reviews)

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HIT ID:HIT107619348
Cas No:875158-73-9
常用名:M04
IUPAC:2-(cyclohexanesulfonyl)-N,N-dimethyl-4-(4-methylbenzenesulfonyl)-1,3-thiazol-5-amine
IUPAC:2-(cyclohexanesulfonyl)-N,N-dimethyl-4-(4-methylbenzenesulfonyl)-1,3-thiazol-5-amine
InChI key:ZPAFZCRZMRTBGW-UHFFFAOYSA-N

分子式:C18H24N2O4S3
分子量:428.58
氢键供体数 (HBD):0
氢键受体数 (HBA):4
LogP:4.256
SMILES:CN(C)c1sc(nc1S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)C1CCCCC1
SMILES:CN(C)c1sc(nc1S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)C1CCCCC1

M04 acts as a stimulator of interferon genes (STING) agonist, effectively inducing IFN reporter gene expression in HEK293T cells equipped with wild-type human STING. Its activity is specific, not affecting HEK293T cells with the R71H-G230A-R293Q (HAQ) human STING variant or mouse RAW 264.7 cells, showcasing allelic- and species-dependent effects at a concentration of 75 µM. This compound also stimulates the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At 50 µM, M04 enhances human monocyte-derived dendritic cells' expression of HLA-DR (MHC class II receptor) and co-stimulatory molecules CD40, CD80, and CD86, improving T cell cross-priming in an ex vivo assay.

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