Name: KAL-21404358
Rating: 5 (10 reviews)

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HIT ID:HIT211756008
Cas No:1065573-84-3
常用名:KAL-21404358
IUPAC:2-{[4-(2,2-dimethylpropyl)-3-(2-hydroxyethyl)piperazin-1-yl]methyl}quinolin-4-ol
IUPAC:2-{[4-(2,2-dimethylpropyl)-3-(2-hydroxyethyl)piperazin-1-yl]methyl}quinolin-4-ol
InChI key:WMHDCRWFBUKCAO-UHFFFAOYSA-N

分子式:C21H31N3O2
分子量:357.498
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)(C)CN1CCN(Cc2cc(O)c3ccccc3n2)CC1CCO
SMILES:CC(C)(C)CN1CCN(Cc2cc(O)c3ccccc3n2)CC1CCO

KAL-21404358 is a Novel allosteric inhibitor of K-RasG12D, binding to the P110 site of K-RasG12D, impairing the K-RasG12D interaction with B-Raf, and disrupting the RAF-MEK-ERK and the PI3K-AKT signaling pathway.

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