Name: ISRIB (trans-isomer)
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212000037
Cas No:1597403-47-8
常用名:ISRIB (trans-isomer)
别名:ISRIB trans-isomer
IUPAC:2-(4-chlorophenoxy)-N-[(1r,4r)-4-[2-(4-chlorophenoxy)acetamido]cyclohexyl]acetamide
IUPAC:2-(4-chlorophenoxy)-N-[(1r,4r)-4-[2-(4-chlorophenoxy)acetamido]cyclohexyl]acetamide
InChI key:HJGMCDHQPXTGAV-IYARVYRRSA-N

分子式:C22H24Cl2N2O4
分子量:451.34
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:3.559801
SMILES:Clc1ccc(OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COc2ccc(Cl)cc2)cc1 |wU:10.9,wD:13.16,(12,-3.85,;10.67,-3.08,;10.67,-1.54,;9.34,-.77,;8,-1.54,;6.67,-.77,;5.33,-1.54,;4,-.77,;4,.77,;2.67,-1.54,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;,1.54,;1.33,.77,;-2.67,1.54,;-4,.77,;-4,-.77,;-5.33,1.54,;-6.67,.77,;-8,1.54,;-8,3.08,;-9.34,3.85,;-10.67,3.08,;-12,3.85,;-10.67,1.54,;-9.34,.77,;8,-3.08,;9.34,-3.85,)|
SMILES:Clc1ccc(OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COc2ccc(Cl)cc2)cc1 |wU:10.9,wD:13.16,(12,-3.85,;10.67,-3.08,;10.67,-1.54,;9.34,-.77,;8,-1.54,;6.67,-.77,;5.33,-1.54,;4,-.77,;4,.77,;2.67,-1.54,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;,1.54,;1.33,.77,;-2.67,1.54,;-4,.77,;-4,-.77,;-5.33,1.54,;-6.67,.77,;-8,1.54,;-8,3.08,;-9.34,3.85,;-10.67,3.08,;-12,3.85,;-10.67,1.54,;-9.34,.77,;8,-3.08,;9.34,-3.85,)|

ISRIB (trans-isomer) 是一种 PERK 的高效抑制剂 (IC50=5 nM)，可以在 P-eIF2α 存在的情况下恢复蛋白质翻译并防止 SG 形成。

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