Name: ML-291
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT212000159
Cas No:1523437-16-2
常用名:ML-291
IUPAC:N-{4-[(4-chloropiperidin-1-yl)sulfonyl]phenyl}-5-nitrofuran-2-carboxamide
IUPAC:N-{4-[(4-chloropiperidin-1-yl)sulfonyl]phenyl}-5-nitrofuran-2-carboxamide
InChI key:XKMLYHZJKCRLOI-UHFFFAOYSA-N

分子式:C16H16ClN3O6S
分子量:413.83
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:1.8806868
SMILES:[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCC(Cl)CC1
SMILES:[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCC(Cl)CC1

ML291 is a sufonamidebenzamide compound that induces the unfolded protein response (UPR) and overwhelms the adaptive capacity of UPR, resulting in apoptosis in various solid cancer models. It activates the PERK/eIF2a/CHOP apoptotic pathway of UPR and reduces leukemic cell burden [1].

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