Name: TPA-023B
Rating: 5 (10 reviews)

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HIT ID:HIT212005308
Cas No:425377-76-0
常用名:TPA-023B
IUPAC:2',6-difluoro-5'-[3-(2-hydroxypropan-2-yl)imidazo[1,2-b][1,2,4]triazin-7-yl]-[1,1'-biphenyl]-2-carbonitrile
IUPAC:2',6-difluoro-5'-[3-(2-hydroxypropan-2-yl)imidazo[1,2-b][1,2,4]triazin-7-yl]-[1,1'-biphenyl]-2-carbonitrile
InChI key:PCZLQMGFNUNVOM-UHFFFAOYSA-N

分子式:C21H15F2N5O
分子量:391.382
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:3.3723223
SMILES:CC(C)(O)c1cnn2c(cnc2n1)-c1ccc(F)c(c1)-c1c(F)cccc1C#N
SMILES:CC(C)(O)c1cnn2c(cnc2n1)-c1ccc(F)c(c1)-c1c(F)cccc1C#N

TPA-023B is an orally active and high-affinity agonist of the GABAA receptor α2/α3 subtype (Kis: 0.73 nM/2 nM) partial and an antagonist α1 subtype (Ki: 1.8 nM), has non-sedating anxiolytic-like properties.

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