Name: UNC569
Rating: 5 (10 reviews)

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HIT ID:HIT212005320
Cas No:1350547-65-7
常用名:UNC569
别名:UNC 569
IUPAC:N-butyl-3-(4-fluorophenyl)-1-{[(1r,4r)-4-aminocyclohexyl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-6-amine
IUPAC:N-butyl-3-(4-fluorophenyl)-1-{[(1r,4r)-4-aminocyclohexyl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-6-amine
InChI key:OGEBRHQLRGFBNV-RZDIXWSQSA-N

分子式:C22H29FN6
分子量:396.514
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:4.135859
SMILES:CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1 |wU:13.12,wD:16.16,(9.11,-4.48,;7.77,-3.71,;7.77,-2.17,;6.44,-1.4,;6.44,.14,;5.11,.91,;5.11,2.45,;3.77,3.22,;2.44,2.45,;.98,2.92,;.07,1.68,;.98,.43,;.5,-1.03,;-1.01,-1.35,;-1.48,-2.82,;-2.99,-3.14,;-4.02,-1.99,;-5.53,-2.31,;-3.54,-.53,;-2.04,-.21,;2.44,.91,;3.77,.14,;.5,4.39,;-1.01,4.71,;-1.48,6.17,;-.45,7.32,;-.93,8.78,;1.05,7,;1.53,5.53,)|
SMILES:CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1 |wU:13.12,wD:16.16,(9.11,-4.48,;7.77,-3.71,;7.77,-2.17,;6.44,-1.4,;6.44,.14,;5.11,.91,;5.11,2.45,;3.77,3.22,;2.44,2.45,;.98,2.92,;.07,1.68,;.98,.43,;.5,-1.03,;-1.01,-1.35,;-1.48,-2.82,;-2.99,-3.14,;-4.02,-1.99,;-5.53,-2.31,;-3.54,-.53,;-2.04,-.21,;2.44,.91,;3.77,.14,;.5,4.39,;-1.01,4.71,;-1.48,6.17,;-.45,7.32,;-.93,8.78,;1.05,7,;1.53,5.53,)|

UNC569 (UNC 569) 是一种ATP 竞争性的、可逆、具有口服活性的Mer 激酶抑制剂，其IC50=2.9 nM，Ki=4.3 nM。它还抑制Axl 和Tyro3，IC50分别为 37 nM 和 48 nM。它可用于研究急性淋巴细胞白血病和非典型畸胎瘤/横纹肌瘤。

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