Name: GNF179 (Metabolite)
Rating: 5 (10 reviews)

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HIT ID:HIT212007853
Cas No:1310455-86-7
常用名:GNF179 (Metabolite)
别名:GNF179 Metabolite
IUPAC:2-(4-fluorophenyl)-8,8-dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine
IUPAC:2-(4-fluorophenyl)-8,8-dimethyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine
InChI key:GZVLWGZMELYUPG-UHFFFAOYSA-N

分子式:C14H16FN3
分子量:245.301
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:2.71575
SMILES:CC1(C)NCCn2cc(nc12)-c1ccc(F)cc1
SMILES:CC1(C)NCCn2cc(nc12)-c1ccc(F)cc1

GNF179 Metabolite, the derivative of GNF179—an optimized 8,8-dimethyl IP analog—demonstrates significant potency (4.8 nM against the multidrug-resistant W2 strain) alongside in vitro metabolic stability and in vivo oral bioavailability.

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