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HIT212013339
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HIT212013339
  • HIT ID:HIT212013339
  • Cas No:17643-36-6
  • 常用名:9-Decyn-1-ol
  • IUPAC:dec-9-yn-1-ol
    IUPAC:dec-9-yn-1-ol
  • InChI key:KOAOUMQUUZNRLL-UHFFFAOYSA-N
  • 分子式:C10H18O
  • 分子量:154.253
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):1
  • LogP:2.665579
  • SMILES:OCCCCCCCCC#C
    SMILES:OCCCCCCCCC#C
  • 9-Decyn-1-ol is an alkyl/ether-based PROTAC linker suitable for synthesizing PROTACs. It serves as a conjugation agent to combine GDC-0068 and Lenalidomide, resulting in the formation of INY-03-041. INY-03-041 is a potent and highly selective pan-Akt degrader that operates through the PROTAC mechanism. It effectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively[1].
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  • 供应商
    TargetMolSC
    规格
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    5日内发货
    纯度
    -
    ¥ 218.00
    1

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