Name: p-nitro-Pifithrin-α
Rating: 5 (10 reviews)

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HIT ID:HIT212017714
Cas No:389850-21-9
常用名:p-nitro-Pifithrin-α
IUPAC:2-(2-imino-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethan-1-one hydrobromide
IUPAC:2-(2-imino-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethan-1-one hydrobromide
InChI key:NXPCMOGORSWOLH-YFKNTREVSA-N

分子式:C15H16BrN3O3S
分子量:398.28
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:2.9861228
SMILES:Br.[O-][N+](=O)c1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N
SMILES:Br.[O-][N+](=O)c1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N

p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].

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