Name: rac-Desethyl Oxybutynin (hydrochloride)
Rating: 5 (10 reviews)

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HIT ID:HIT212023403
Cas No:81039-77-2
常用名:rac-Desethyl Oxybutynin (hydrochloride)
常用名:rac-Desethyl Oxybutynin (hydrochloride)
IUPAC:4-(ethylamino)but-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride
IUPAC:4-(ethylamino)but-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride
InChI key:DSWCYTSHCYXHGW-UHFFFAOYSA-N

分子式:C20H28ClNO3
分子量:365.9
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:3.6982195
SMILES:Cl.CCNCC#CCOC(=O)C(O)(C1CCCCC1)c1ccccc1
SMILES:Cl.CCNCC#CCOC(=O)C(O)(C1CCCCC1)c1ccccc1

rac-Desethyl oxybutynin is an active metabolite of the muscarinic acetylcholine receptor (mAChR) antagonist oxybutynin .1,2,3rac-Desethyl oxybutynin is formed from oxybutynin by the cytochrome P450 (CYP) isoform CYP3A4.2It binds to mAChRs in isolated rat bladder, submaxillary gland, heart, and colon with Kivalues of 5.38, 3.12, 16, and 5.59 nM, respectively.rac-Desethyl oxybutynin (0.4 and 0.8 mg/kg) reduces micturition pressure in rats.3

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