Name: N-desmethyl Rosiglitazone
Rating: 5 (10 reviews)

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HIT ID:HIT212023541
Cas No:257892-31-2
常用名:N-desmethyl Rosiglitazone
IUPAC:5-[(4-{2-[(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione
IUPAC:5-[(4-{2-[(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione
InChI key:ZJQTVMXUIGXRMR-UHFFFAOYSA-N

分子式:C17H17N3O3S
分子量:343.4
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:2.2025104
SMILES:O=C1NC(=O)C(Cc2ccc(OCCNc3ccccn3)cc2)S1
SMILES:O=C1NC(=O)C(Cc2ccc(OCCNc3ccccn3)cc2)S1

N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone , a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone.

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