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  3. HIT212034105
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HIT212034105
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HIT212034105
  • HIT ID:HIT212034105
  • Cas No:1537859-24-7
  • 常用名:GNE-3500
  • IUPAC:(3S,6R)-2-{[4-(4-acetylpiperazin-1-yl)-2-fluorophenyl]methyl}-3-methyl-6-phenyl-1lambda6,2-thiazinane-1,1-dione
    IUPAC:(3S,6R)-2-{[4-(4-acetylpiperazin-1-yl)-2-fluorophenyl]methyl}-3-methyl-6-phenyl-1lambda6,2-thiazinane-1,1-dione
  • InChI key:WLCIIQPUMOJJOF-MHECFPHRSA-N
  • 分子式:C24H30FN3O3S
  • 分子量:459.58
  • 氢键供体数 (HBD):0
  • 氢键受体数 (HBA):4
  • LogP:2.8723266
  • SMILES:C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1ccc(cc1F)N1CCN(CC1)C(C)=O
    SMILES:C[C@H]1CC[C@H](c2ccccc2)S(=O)(=O)N1Cc1ccc(cc1F)N1CCN(CC1)C(C)=O
  • GNE-3500 is a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist. Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse agonists as potential treatments of inflammatory diseases such as psoriasis and rheumatoid arthritis. GNE-3500 possessed favorable RORc cellular potency with 75-fold selectivity for RORc over other ROR family members and >200-fold selectivity over 25 additional nuclear receptors in a cell assay panel. The favorable potency, selectivity, in vitro ADME properties, in vivo PK, and dose-dependent inhibition of IL-17 in a PK/PD model support the evaluation of GNE3500 in preclinical studies (J. Med. Chem., 2015, 58 (13), pp 5308–5322)
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1
  • 供应商
    BIONET-Key OrganicsBB
    规格
    货期
    4-6周
    纯度
    -
    ¥ 12,038.00
    1

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