Name: FMOC-L-THR
Rating: 5 (10 reviews)

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HIT ID:HIT212036949
Cas No:160168-40-1
常用名:FMOC-L-THR
IUPAC:(2S,3R)-3-{[(2R,3R,4R,5S,6R)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]-3-acetamidooxan-2-yl]oxy}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
IUPAC:(2S,3R)-3-{[(2R,3R,4R,5S,6R)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]-3-acetamidooxan-2-yl]oxy}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
InChI key:OXLCJWGAUPPZQJ-WPYJLJGXSA-N

分子式:C33H38N2O13
分子量:670.668
氢键供体数 (HBD):3
氢键受体数 (HBA):9
LogP:1.6794876
SMILES:C[C@@H](O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1NC(C)=O)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O
SMILES:C[C@@H](O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1NC(C)=O)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O

FMOC-L-THR (AZP-531) is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen)[1].

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