Name: BX471 hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212037284
Cas No:288262-96-4
常用名:BX471 hydrochloride
别名:ZK-811752 hydrochloride
IUPAC:(5-chloro-2-{2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy}phenyl)urea hydrochloride
IUPAC:(5-chloro-2-{2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy}phenyl)urea hydrochloride
InChI key:FRUCNQBAWUHKLS-PFEQFJNWSA-N

分子式:C21H25Cl2FN4O3
分子量:471.35
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:2.5730464
SMILES:Cl.C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O
SMILES:Cl.C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O

BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4.

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