Name: ZK824859
Rating: 5 (10 reviews)

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HIT ID:HIT212037473
Cas No:2271122-53-1
常用名:ZK824859
IUPAC:(2R)-2-[(6-{[3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl]oxy}-3,5-difluoropyridin-2-yl)oxy]butanoic acid
IUPAC:(2R)-2-[(6-{[3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl]oxy}-3,5-difluoropyridin-2-yl)oxy]butanoic acid
InChI key:CVNXUNVHFJANHX-HXUWFJFHSA-N

分子式:C23H22F2N2O4
分子量:428.436
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:3.1653218
SMILES:CC[C@@H](Oc1nc(Oc2cc(C)cc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O
SMILES:CC[C@@H](Oc1nc(Oc2cc(C)cc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O

ZK824859 is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).

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