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  3. HIT212038300
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HIT212038300
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HIT212038300
  • HIT ID:HIT212038300
  • Cas No:858102-79-1;914462-92-3
  • 常用名:SCH619734 SCH-619734
  • IUPAC:(5S,8S)-8-{[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl}-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrate hydrochloride
    IUPAC:(5S,8S)-8-{[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl}-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrate hydrochloride
  • InChI key:GZQWMYVDLCUBQX-WVZIYJGPSA-N
  • 分子式:C25H29ClF6N2O3
  • 分子量:554.96
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):3
  • LogP:5.003099
  • SMILES:O.Cl.C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
    SMILES:O.Cl.C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
  • Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy.
市场产品/服务共显示3个结果
  • 供应商
    TargetMolSC
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    5日内发货
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    ¥ 5,944.00
    1
  • 供应商
    TargetMolSC
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    货期
    1-2周
    纯度
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    ¥ 18,300.00
    1
  • 供应商
    BIONET-Key OrganicsBB
    规格
    货期
    4-6周
    纯度
    -
    ¥ 3,678.00
    1

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