Name: 5-Methoxycanthin-6-one
Rating: 5 (10 reviews)

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HIT ID:HIT212038689
Cas No:15071-56-4
常用名:5-Methoxycanthin-6-one
IUPAC:3-methoxy-1,6-diazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one
IUPAC:3-methoxy-1,6-diazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one
InChI key:TXEFUSAHPIYZHD-UHFFFAOYSA-N

分子式:C15H10N2O2
分子量:250.257
氢键供体数 (HBD):0
氢键受体数 (HBA):3
LogP:1.679
SMILES:COc1cc2nccc3c4ccccc4n(c23)c1=O
SMILES:COc1cc2nccc3c4ccccc4n(c23)c1=O

5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 uM versus doxorubicine with IC50 = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosis response upon activation with serum-opsonized zymosan in the range of IC50 = 0.9-2.0 uM versus ibuprofen with IC50 = 12.1 uM.

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