Name: Butyrolactone V
Rating: 5 (10 reviews)

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HIT ID:HIT212038782
Cas No:1151509-01-1
常用名:Butyrolactone V
IUPAC:methyl (2R)-4-hydroxy-2-{[(3S)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]methyl}-3-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate
IUPAC:methyl (2R)-4-hydroxy-2-{[(3S)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]methyl}-3-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate
InChI key:NSXYYYUKWBLFQH-MHECFPHRSA-N

分子式:C24H24O8
分子量:440.448
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:3.1042511
SMILES:COC(=O)[C@]1(Cc2ccc3OC(C)(C)[C@@H](O)Cc3c2)OC(=O)C(O)=C1c1ccc(O)cc1 |c:25|
SMILES:COC(=O)[C@]1(Cc2ccc3OC(C)(C)[C@@H](O)Cc3c2)OC(=O)C(O)=C1c1ccc(O)cc1 |c:25|

Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 μM, respectively).1

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