Name: Nargenicin
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212039020
Cas No:70695-02-2
常用名:Nargenicin
别名:Antibiotic 47444
IUPAC:(1S,3R,4R,5R,6R,7S,8R,11S,13S,16S,17R,18E)-6-hydroxy-16-[(1R)-1-hydroxyethyl]-13-methoxy-5,17,19-trimethyl-14-oxo-2,15-dioxatetracyclo[9.8.0.0^{1,7}.0^{3,8}]nonadeca-9,18-dien-4-yl 1H-pyrrole-2-carboxylate
IUPAC:(1S,3R,4R,5R,6R,7S,8R,11S,13S,16S,17R,18E)-6-hydroxy-16-[(1R)-1-hydroxyethyl]-13-methoxy-5,17,19-trimethyl-14-oxo-2,15-dioxatetracyclo[9.8.0.0^{1,7}.0^{3,8}]nonadeca-9,18-dien-4-yl 1H-pyrrole-2-carboxylate
InChI key:YEUSSARNQQYBKH-SIMZXIQRSA-N

分子式:C28H37NO8
分子量:515.603
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:2.145281
SMILES:[H][C@]12C=C[C@]3([H])C[C@H](OC)C(=O)O[C@]([H])([C@@H](C)O)[C@H](C)\C=C(C)\[C@]33O[C@H]1[C@H](OC(=O)c1ccc[nH]1)[C@H](C)[C@@H](O)[C@]23[H] |c:2,20,TLB:4:23:1:35.26.37,THB:26:25:39:2.3.4,21:23:1:35.26.37|
SMILES:[H][C@]12C=C[C@]3([H])C[C@H](OC)C(=O)O[C@]([H])([C@@H](C)O)[C@H](C)\C=C(C)\[C@]33O[C@H]1[C@H](OC(=O)c1ccc[nH]1)[C@H](C)[C@@H](O)[C@]23[H] |c:2,20,TLB:4:23:1:35.26.37,THB:26:25:39:2.3.4,21:23:1:35.26.37|

Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (1 μM) inhibits cytokine expression and nitric oxide production induced by LPS.[3] Nargenicin (200 μM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid , reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells.[4]

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~