Name: Reveromycin B
Rating: 5 (10 reviews)

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HIT ID:HIT212039097
Cas No:144860-68-4
常用名:Reveromycin B
IUPAC:(2E,4S,5S,6E,8E)-10-[(2R,5S,7R,8S)-2-butyl-2-[(1S,2E,4E)-5-carboxy-1-[(3-carboxypropanoyl)oxy]-4-methylpenta-2,4-dien-1-yl]-8-methyl-1,6-dioxaspiro[4.5]decan-7-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid
IUPAC:(2E,4S,5S,6E,8E)-10-[(2R,5S,7R,8S)-2-butyl-2-[(1S,2E,4E)-5-carboxy-1-[(3-carboxypropanoyl)oxy]-4-methylpenta-2,4-dien-1-yl]-8-methyl-1,6-dioxaspiro[4.5]decan-7-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid
InChI key:XVFQIVPMOPJEIO-OXVOKJAASA-N

分子式:C36H52O11
分子量:660.801
氢键供体数 (HBD):4
氢键受体数 (HBA):10
LogP:5.9440227
SMILES:CCCC[C@@]1(CC[C@]2(CC[C@H](C)[C@@H](C\C=C(/C)\C=C\[C@H](O)[C@@H](C)\C=C\C(O)=O)O2)O1)[C@@H](OC(=O)CCC(O)=O)\C=C\C(\C)=C\C(O)=O
SMILES:CCCC[C@@]1(CC[C@]2(CC[C@H](C)[C@@H](C\C=C(/C)\C=C\[C@H](O)[C@@H](C)\C=C\C(O)=O)O2)O1)[C@@H](OC(=O)CCC(O)=O)\C=C\C(\C)=C\C(O)=O

Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 μg/ml) and exhibits pH-dependent antifungal activity against C. albicans (MICs = 15.6 and >500 μg/ml at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C , reveromycin B does not inhibit proliferation of KB and K562 cells.

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