Name: Violacein
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212039178
Cas No:548-54-9
常用名:Violacein
IUPAC:3-[(3E)-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-2,3-dihydro-1H-pyrrol-3-ylidene]-2,3-dihydro-1H-indol-2-one
IUPAC:3-[(3E)-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-2,3-dihydro-1H-pyrrol-3-ylidene]-2,3-dihydro-1H-indol-2-one
InChI key:XAPNKXIRQFHCHN-QGOAFFKASA-N

分子式:C20H13N3O3
分子量:343.342
氢键供体数 (HBD):4
氢键受体数 (HBA):3
LogP:1.6741608
SMILES:Oc1ccc2[nH]cc(C3=C\C(C(=O)N3)=C3/C(=O)Nc4ccccc34)c2c1 |t:8|
SMILES:Oc1ccc2[nH]cc(C3=C\C(C(=O)N3)=C3/C(=O)Nc4ccccc34)c2c1 |t:8|

Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 &#181M, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 &#181M, respectively).[2] It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.[1]

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~