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- HIT ID:HIT212039195
- Cas No:26052-96-0
- 常用名:β-Carboline-1-carboxylic acid
- InChI key:VNPNEGORDFERGK-UHFFFAOYSA-N
- 分子式:C12H8N2O2
- 分子量:212.208
- 氢键供体数 (HBD):2
- 氢键受体数 (HBA):3
- LogP:0.32966635
- β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells. β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 µg/ml, respectively). It also inhibits cAMP phosphodiesterase with an IC50 value of 96 µM.
市场产品/服务共显示4个结果
- 供应商TargetMol规格货期35日内发货纯度-¥ 4,600.001
- 供应商Enamine规格货期4-6周纯度-¥ 2,402.001
- 供应商BIONET-Key Organics规格货期4-6周纯度-待询1
- 供应商AA Blocks规格货期4-6周纯度-待询1
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