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HIT212044468
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HIT212044468
  • HIT ID:HIT212044468
  • Cas No:3187-58-4
  • 常用名:Methyl orsellinate
  • IUPAC:methyl 2,4-dihydroxy-6-methylbenzoate
    IUPAC:methyl 2,4-dihydroxy-6-methylbenzoate
  • InChI key:NCCWCZLEACWJIN-UHFFFAOYSA-N
  • 分子式:C9H10O4
  • 分子量:182.175
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):3
  • LogP:2.533
  • SMILES:COC(=O)c1c(C)cc(O)cc1O
    SMILES:COC(=O)c1c(C)cc(O)cc1O
  • Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. Methyl orsellinate can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, the selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity, methyl orsellinate may can treat the type 2 diabetes and obesity.
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