Name: SC-10914
Rating: 5 (10 reviews)

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HIT ID:HIT212055130
Cas No:76985-08-5
常用名:SC-10914
IUPAC:2-amino-3-{[1,1'-biphenyl]-4-yl}propanoic acid
IUPAC:2-amino-3-{[1,1'-biphenyl]-4-yl}propanoic acid
InChI key:JCZLABDVDPYLRZ-UHFFFAOYSA-N

分子式:C15H15NO2
分子量:241.29
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:0.46282044
SMILES:NC(Cc1ccc(cc1)-c1ccccc1)C(O)=O
SMILES:NC(Cc1ccc(cc1)-c1ccccc1)C(O)=O

SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 μM). SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers.

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