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  3. HIT212074870
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HIT212074870
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HIT212074870
  • HIT ID:HIT212074870
  • Cas No:1185039-30-8
  • 常用名:Gliclazide-d4
  • IUPAC:1-[4-methyl(2,3,5,6-2H4)benzenesulfonyl]-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea
    IUPAC:1-[4-methyl(2,3,5,6-2H4)benzenesulfonyl]-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea
  • InChI key:BOVGTQGAOIONJV-KDWZCNHSSA-N
  • 分子式:C15H21N3O3S
  • 分子量:327.44
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):4
  • LogP:1.733641
  • SMILES:[2H]c1c([2H])c(c([2H])c([2H])c1C)S(=O)(=O)NC(=O)NN1CC2CCCC2C1
    SMILES:[2H]c1c([2H])c(c([2H])c([2H])c1C)S(=O)(=O)NC(=O)NN1CC2CCCC2C1
  • Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide. Gliclazide (5 and 10 μg/ml) reduces LDL oxidation by human aortic smooth muscle cells (HASMCs), decreasing TBARS content and 8-isoprostane levels. It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 μg/ml. Gliclazide (5 mg/kg) reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin (STZ).
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 3,230.00
    1

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