Name: Clozapine HCl
Rating: 5 (10 reviews)

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HIT ID:HIT212078982
Cas No:54241-01-9
常用名:Clozapine HCl
IUPAC:6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene hydrochloride
IUPAC:6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene hydrochloride
InChI key:VFDNENKXDGAOSN-UHFFFAOYSA-N

分子式:C18H20Cl2N4
分子量:363.29
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:3.5154991683333328
SMILES:Cl.CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15|
SMILES:Cl.CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15|

Clozapine HCl is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

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