SGK1 inhibitor | CAS 1426214-51-8 | AnyMole

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HIT212080394

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HIT212080394

HIT ID:HIT212080394
Cas No:1426214-51-8
常用名:SGK1 inhibitor
IUPAC:N-(4-{3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl}phenyl)-2,3-dichlorobenzene-1-sulfonamide
IUPAC:N-(4-{3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl}phenyl)-2,3-dichlorobenzene-1-sulfonamide
InChI key:MBNNXCKHRKSGSU-UHFFFAOYSA-N

分子式:C17H12Cl2N6O2S
分子量:435.28
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:3.108637
SMILES:Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1
SMILES:Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1

SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719.

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