Name: PROTAC Sirt2 Degrader-1
Rating: 5 (10 reviews)

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HIT ID:HIT212080429
Cas No:2098487-75-1
常用名:PROTAC Sirt2 Degrader-1
IUPAC:N-{4-[4-({3-[(2-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamido}-1,3-thiazol-5-yl)methyl]phenoxy}methyl)-1H-1,2,3-triazol-1-yl]butyl}-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
IUPAC:N-{4-[4-({3-[(2-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamido}-1,3-thiazol-5-yl)methyl]phenoxy}methyl)-1H-1,2,3-triazol-1-yl]butyl}-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
InChI key:GRYRXFYWVDWPQY-UHFFFAOYSA-N

分子式:C40H40N10O8S2
分子量:852.94
氢键供体数 (HBD):3
氢键受体数 (HBA):13
LogP:2.618
SMILES:Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(CCCCNC(=O)COc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)nn4)c3)s2)n1
SMILES:Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(CCCCNC(=O)COc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)nn4)c3)s2)n1

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].

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