Name: (S,R,S)-AHPC-PEG6-C4-Cl
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212080444
Cas No:1835705-59-3
常用名:(S,R,S)-AHPC-PEG6-C4-Cl
别名:VHL Ligand-Linker Conjugates 10, VH032-PEG6-C4-Cl, E3 ligase Ligand-Linker Conjugates 9
别名:VHL Ligand-Linker Conjugates 10, VH032-PEG6-C4-Cl, E3 ligase Ligand-Linker Conjugates 9
IUPAC:(2S,4R)-1-[(2S)-2-(24-chloro-3,6,9,12,15,18-hexaoxatetracosanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
IUPAC:(2S,4R)-1-[(2S)-2-(24-chloro-3,6,9,12,15,18-hexaoxatetracosanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
InChI key:XIGXWMDJELQVSW-WYMKREKISA-N

分子式:C40H63ClN4O10S
分子量:827.47
氢键供体数 (HBD):3
氢键受体数 (HBA):11
LogP:2.391332
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCCCCCCl)C(C)(C)C)cc1
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCCCCCCl)C(C)(C)C)cc1

(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~