Name: BI-3663
Rating: 5 (10 reviews)

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HIT ID:HIT212080518
Cas No:2341740-84-7
常用名:BI-3663
IUPAC:N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide
IUPAC:N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide
InChI key:ADTXLFJKQHYGPM-UHFFFAOYSA-N

分子式:C44H42F3N7O12
分子量:917.852
氢键供体数 (HBD):4
氢键受体数 (HBA):14
LogP:3.6218288
SMILES:COc1cc(ccc1Nc1ncc(c(Oc2cccc3CCC(=O)c23)n1)C(F)(F)F)C(=O)NCCOCCOCCOCCC(=O)Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
SMILES:COc1cc(ccc1Nc1ncc(c(Oc2cccc3CCC(=O)c23)n1)C(F)(F)F)C(=O)NCCOCCOCCOCCC(=O)Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer.

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