Name: Thalidomide-O-PEG2-propargyl
Rating: 5 (10 reviews)

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HIT ID:HIT212080562
Cas No:2098487-52-4
常用名:Thalidomide-O-PEG2-propargyl
别名:E3 ligase Ligand-Linker Conjugates 32
IUPAC:2-(2,6-dioxopiperidin-3-yl)-4-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC:2-(2,6-dioxopiperidin-3-yl)-4-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}-2,3-dihydro-1H-isoindole-1,3-dione
InChI key:XJWGDRINRIEEJD-UHFFFAOYSA-N

分子式:C20H20N2O7
分子量:400.387
氢键供体数 (HBD):1
氢键受体数 (HBA):7
LogP:-0.00783188
SMILES:O=C1N(C2CCC(=O)NC2=O)C(=O)c2c1cccc2OCCOCCOCC#C
SMILES:O=C1N(C2CCC(=O)NC2=O)C(=O)c2c1cccc2OCCOCCOCC#C

Thalidomide-O-PEG2-propargyl (E3 Ligase Ligand-Linker Conjugates 32) is a chemical compound that has been synthesized as a conjugate of an E3 ligase ligand and a linker. It incorporates the cereblon ligand based on Thalidomide, along with a 2-unit PEG linker. This compound is specifically designed for use in PROTAC technology, which utilizes ligand-induced protein degradation [1].

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