Name: Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
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HIT ID:HIT212080563
Cas No:2245697-84-9
常用名:Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
常用名:Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
IUPAC:N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide hydrochloride
IUPAC:N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide hydrochloride
InChI key:ORRMBTUTYKQYQU-UHFFFAOYSA-N

分子式:C23H31ClN4O9
分子量:542.97
氢键供体数 (HBD):3
氢键受体数 (HBA):10
LogP:-0.951
SMILES:Cl.NCCOCCOCCOCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
SMILES:Cl.NCCOCCOCCOCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. It is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1].

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