Name: 15(R)-Prostaglandin E2
Rating: 5 (10 reviews)

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HIT ID:HIT212089925
Cas No:363-24-6
常用名:15(R)-Prostaglandin E2
别名:15-epi PGE2
IUPAC:7-[3-hydroxy-2-(3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl]hept-5-enoic acid
IUPAC:7-[3-hydroxy-2-(3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl]hept-5-enoic acid
InChI key:XEYBRNLFEZDVAW-UHFFFAOYSA-N

分子式:C20H32O5
分子量:352.471
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:3.22527
SMILES:CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O |w:7.6,17.17|
SMILES:CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O |w:7.6,17.17|

15(R)-Prostaglandin E2, the C-15 epimer of the more physiologically abundant 15(S)-PGE2 (sc-201225) isomer, is produced mainly from arachidonic acid (sc-200770) via the action of COX and PGES enzymes. Present in nearly all cell types, PGE2 interacts with four distinct receptors, EP1 to EP4, leading to a wide range of biological effects. However, 15(R)-Prostaglandin E2 exhibits significantly lower efficacy in most biological assays compared to its 15(S) counterpart. Notably, acid catalyzed epimerization can transform 15(R)-Prostaglandin E2 into the more active 15(S)-Prostaglandin E2 form.

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