Name: Nafoxidine HCl(1845-11-0 Free base)
Rating: 5 (10 reviews)

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HIT ID:HIT212090115
Cas No:1847-63-8
常用名:Nafoxidine HCl(1845-11-0 Free base)
常用名:Nafoxidine HCl(1845-11-0 Free base)
别名:PNU-0011100, PNU0011100, PNU 0011100, Nafoxidine HCl, CP-5600, CP5600, CP 5600
别名:PNU-0011100, PNU0011100, PNU 0011100, Nafoxidine HCl, CP-5600, CP5600, CP 5600
IUPAC:1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride
IUPAC:1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride
InChI key:HJOOGTROABIIIU-UHFFFAOYSA-N

分子式:C29H32ClNO2
分子量:462.03
氢键供体数 (HBD):0
氢键受体数 (HBA):3
LogP:6.204475
SMILES:Cl.COc1ccc2C(=C(CCc2c1)c1ccccc1)c1ccc(OCCN2CCCC2)cc1 |c:6|
SMILES:Cl.COc1ccc2C(=C(CCc2c1)c1ccccc1)c1ccc(OCCN2CCCC2)cc1 |c:6|

Nafoxidine is a partial estrogen antagonist. It inhibits angiogenesis in some tissues by blocking the effects of VEGF and FGF; paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces calcium signaling, oxidative stress, and protein kinase C.

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