Name: Gliovirin
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212101535
Cas No:83912-90-7
常用名:Gliovirin
IUPAC:8-hydroxy-14-(2-hydroxy-3,4-dimethoxyphenyl)-4,10-dioxa-15,16-dithia-11,18-diazapentacyclo[11.3.2.0^{1,11}.0^{3,5}.0^{3,9}]octadec-6-ene-12,17-dione
IUPAC:8-hydroxy-14-(2-hydroxy-3,4-dimethoxyphenyl)-4,10-dioxa-15,16-dithia-11,18-diazapentacyclo[11.3.2.0^{1,11}.0^{3,5}.0^{3,9}]octadec-6-ene-12,17-dione
InChI key:VZUFPCHAVLFFAY-UHFFFAOYSA-N

分子式:C20H20N2O8S2
分子量:480.51
氢键供体数 (HBD):3
氢键受体数 (HBA):8
LogP:0.87850195
SMILES:COc1ccc(C2SSC34CC56OC5C=CC(O)C6ON3C(=O)C2NC4=O)c(O)c1OC |c:15,THB:5:6:25.24:20.21|
SMILES:COc1ccc(C2SSC34CC56OC5C=CC(O)C6ON3C(=O)C2NC4=O)c(O)c1OC |c:15,THB:5:6:25.24:20.21|

Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decreases phorbol 12-myristate 13-acetate (TPA)- and ionomycin-induced increased expression of COX-2 (IC50= 1 μM) and protein levels of IL-2 in Jurkat cells (IC50= 5.2 μM).1

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~