Name: TRPC3/6-IN-1
Rating: 5 (10 reviews)

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HIT ID:HIT212227695
Cas No:736945-96-3
常用名:TRPC3/6-IN-1
IUPAC:N-(4-methoxyphenyl)-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1,3-thiazol-2-amine
IUPAC:N-(4-methoxyphenyl)-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1,3-thiazol-2-amine
InChI key:NTXBDULODNTCKP-UHFFFAOYSA-N

分子式:C20H19N3O2S
分子量:365.45
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:4.291
SMILES:COc1ccc(Nc2nc(cs2)C(=O)N2CCc3ccccc3C2)cc1
SMILES:COc1ccc(Nc2nc(cs2)C(=O)N2CCc3ccccc3C2)cc1

TRPC3/6-IN-1 is a highly potent and selective inhibitor that specifically blocks the activity of the canonical transient receptor channels TRPC3 and TRPC6. It exhibits a significant blocking potency against the human isoforms hTRPC3 and hTRPC6, with IC50 values of 1260 nM and 500 nM, respectively. This compound, TRPC3/6-IN-1, is particularly valuable for conducting research on chronic models of heart failure [1].

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